NDLI: EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer.

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EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer.

Content Provider	Europe PMC
Author	Serrano, Maria J. Ortega, Francisco G. Alvarez-Cubero, Maria J. Nadal, Rosa Sanchez-Rovira, Pedro Salido, Marta Rodríguez, María García-Puche, Jose L. Delgado-Rodriguez, Miguel Solé, Francisco García, Maria A. Perán, Macarena Rosell, Rafael Marchal, Juan A. Lorente, Jose A.
Copyright Year	2014
Abstract	Circulating tumor cells (CTCs) are frequently associated with epithelialmesenchymal transition (EMT). The objective of this study was to detect EMT phenotype through Vimentin (VIM) and Slug expression in cytokeratin (CK)-negative CTCs in non-metastatic breast cancer patients and to determine the importance of EGFR in the EMT phenomenon. In CK-negative CTCs samples, both VIM and Slug markers were co-expressed in the most of patients. Among patients EGFR+, half of them were positive for these EMT markers. Furthermore, after a systemic treatment 68% of patients switched from CK- to CK+ CTCs. In our experimental model we found that activation of EGFR signaling by its ligand on MCF-7 cells is sufficient to increase EMT phenotypes, to inhibit apoptotic events and to induce the loss of CK expression. The simultaneous detection of both EGFR and EMT markers in CTCs may improve prognostic or predictive information in patients with operable breast cancer.
Journal	Oncotarget
Volume Number	5
PubMed Central reference number	PMC4202138
Issue Number	17
PubMed reference number	25277187
e-ISSN	19492553
DOI	10.18632/oncotarget.2217
Language	English
Publisher	Impact Journals LLC
Publisher Date	2014-09-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2014 Serrano et al.
Subject Keyword	Breast Cancer Circulating Tumor Cells EGFR Epithelial-Mesenchymal Transition Vimentin Slug Bcl-2 Apoptosis
Content Type	Text
Resource Type	Article
Subject	Oncology

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