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Invasive pneumococcal disease after implementation of 13-valent conjugate vaccine.
| Content Provider | Europe PMC |
|---|---|
| Author | Tam, Pui-Ying Iroh Madoff, Lawrence C. Coombes, Brandon Pelton, Stephen I. |
| Copyright Year | 2014 |
| Abstract | OBJECTIVE: To examine whether there is a different clinical profile and severity of invasive pneumococcal disease (IPD) in children caused by nonvaccine types in the era of 13-valent pneumococcal conjugate vaccine (PCV13). METHODS: Observational study of childhood IPD in Massachusetts based on state public health surveillance data comparing pre-PCV13 (2007–2009) and post-PCV13 (2010–2012) eras. RESULTS: There were 168 pre-PCV13 cases of IPD and 85 post-PCV13 cases of IPD in Massachusetts children ≤5 years of age. PCV13 serotypes declined by 18% in the first 2 years after PCV13 use (P = .011). In the post-PCV13 phase, a higher proportion of children were hospitalized (57.6% vs 50.6%), and a higher proportion of children had comorbidity (23.5% vs 19.6%). Neither difference was statistically significant, nor were comparisons of IPD caused by vaccine and nonvaccine types. Children with comorbidities had higher rates of IPD caused by a nonvaccine type (27.6% vs 17.2%; P = .085), were more likely to be hospitalized (80.4% vs 50%; P < .0001), and were more likely to have a longer hospital stay (median of 3 days vs 0.5 days; P = .0001). CONCLUSIONS: Initial data suggest that nonvaccine serotypes are more common in children with underlying conditions, who have greater morbidity from disease. In the post-PCV13 era, a larger proportion of patients are hospitalized, but mortality rates are unchanged. Routine vaccination with PCV13 may not be enough to reduce the risk in patients with comorbidity. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4187237&blobtype=pdf |
| Page Count | 8 |
| ISSN | 00314005 |
| Volume Number | 134 |
| DOI | 10.1542/peds.2014-0473 |
| PubMed Central reference number | PMC4187237 |
| Issue Number | 2 |
| PubMed reference number | 25002663 |
| Journal | Pediatrics |
| e-ISSN | 10984275 |
| Language | English |
| Publisher | American Academy of Pediatrics |
| Publisher Date | 2014-07-07 |
| Publisher Place | Elk Grove Village, IL, USA |
| Access Restriction | Open |
| Rights License | Copyright © 2014 by the American Academy of Pediatrics |
| Subject Keyword | invasive pneumococcal disease conjugate vaccine children comorbidity severity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
