Antiatherogenic, hepatoprotective, and hypolipidemic effects of coenzyme Q10 in alloxan-induced type 1 diabetic rats.

Content Provider	Europe PMC
Author	Ahmadvand, Hassan Ghasemi-Dehnoo, Maryam
Copyright Year	2014
Abstract	BACKGROUNDDiabetes mellitus, one of the leading metabolic syndromes, accounts for highest morbidity and mortality worldwide. In this study, we examined possible protective effect of coenzyme Q10 on lipid profile, atherogenic index, and liver enzyme markers in alloxan-induced type 1 diabetic rats.METHODSA total of 30 male rats were randomly divided into three groups; group 1 as control, group 2 diabetic untreatment, and group 3 treatments with coenzyme Q10 by 15 mg/kg i.p. daily, respectively .Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, the levels of fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), high density lipoprotein (HDL), atherogenic index, atherogenic coefficient, cardiac risk ratio, and the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) of all groups were analyzed. Data were analyzed using non-parametric Mann-Whitney test (using SPSS) and P < 0.05 was considered as significant.RESULTSCoenzyme Q10 inhibited significantly the activities of ALT (11.17%), AST (19.35%) and ALP (36.67%) and decreased FBG (21.19%), TG (37.24%), TC (17.15%), LDL (30.44%), VLDL (37.24%), atherogenic index (44.24%), atherogenic coefficient (49.69%), and cardiac risk ratio (37.97%), HDL level was significantly (33.38%) increased when treated with coenzyme Q10.CONCLUSIONThe findings of this study suggest that coenzyme Q10 exert beneficial effects on the lipid profile, atherogenic index, and liver enzymes activity in alloxan-induced type 1 diabetic rats.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4173318&blobtype=pdf
ISSN	17353955
Journal	ARYA Atherosclerosis [ARYA Atheroscler]
Volume Number	10
PubMed Central reference number	PMC4173318
Issue Number	4
PubMed reference number	25258634
e-ISSN	22516638
Language	English
Publisher	Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences
Publisher Date	2014-07-01
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. © 2014 Isfahan Cardiovascular Research Center & Isfahan University of Medical Sciences
Subject Keyword	Diabetes Lipid Profile Atherogenic Index Rats Liver Enzymes Coenzyme Q10
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine