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H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC.
| Content Provider | Europe PMC |
|---|---|
| Author | Carotenuto, Marianeve De Antonellis, Pasqualino Liguori, Lucia Benvenuto, Giovanna Magliulo, Daniela Alonzi, Alessandro Turino, Cecilia Attanasio, Carmela Damiani, Valentina Bello, Anna Maria Vitiello, Fabiana Pasquinelli, Rosa Terracciano, Luigi Federico, Antonella Fusco, Alfredo Freeman, Jamie Dale, Trevor C. Decraene, Charles Chiappetta, Gennaro Piantedosi, Francovito Calabrese, Cecilia Zollo, Massimo |
| Copyright Year | 2014 |
| Abstract | H-Prune hydrolyzes short-chain polyphosphates (PPase activity) together with an hitherto cAMP-phosphodiesterase (PDE), the latest influencing different human cancers by its overexpression. H-Prune promotes cell migration in cooperation with glycogen synthase kinase-3 (Gsk-3β). Gsk-3β is a negative regulator of canonical WNT/β-catenin signaling. Here, we investigate the role of Gsk-3β/h-Prune complex in the regulation of WNT/β-catenin signaling, demonstrating the h-Prune capability to activate WNT signaling also in a paracrine manner, through Wnt3a secretion. In vivo study demonstrates that h-Prune silencing inhibits lung metastasis formation, increasing mouse survival. We assessed h-Prune levels in peripheral blood of lung cancer patients using ELISA assay, showing that h-Prune is an early diagnostic marker for lung cancer. Our study dissects out the mechanism of action of h-Prune in tumorigenic cells and also sheds light on the identification of a new therapeutic target in non-small-cell lung cancer. |
| Journal | Oncotarget |
| Volume Number | 5 |
| PubMed Central reference number | PMC4170634 |
| Issue Number | 14 |
| PubMed reference number | 25026278 |
| e-ISSN | 19492553 |
| DOI | 10.18632/oncotarget.2169 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2014-07-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2014 Carotenuto et al. |
| Subject Keyword | h-Prune lung cancer diagnostic marker WNT/β-catenin signalling Gsk-3β Wnt3a |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
