NDLI: Macrophage Infiltration in Tumor Stroma is Related to Tumor Cell Expression of CD163 in Colorectal Cancer.

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Macrophage Infiltration in Tumor Stroma is Related to Tumor Cell Expression of CD163 in Colorectal Cancer.

Content Provider	Europe PMC
Author	Shabo, Ivan Olsson, Hans Elkarim, Rihab Sun, Xiao-Feng Svanvik, Joar
Abstract	The scavenger receptor, CD163, is a macrophage-specific marker. Recent studies have shown that CD163 expression in breast and rectal cancer cells is associated with poor prognosis. This study was conducted to evaluate the relationship between CD163 expression as a macrophage trait in cancer cells, and macrophage infiltration and its clinical significance in colorectal cancer. Immunostaining of CD163 and macrophage infiltration were evaluated in paraffin-embedded specimens, earlier analyzed for CD31, D2-40 and S-phase fraction, from primary tumors and normal colorectal mucosa of 75 patients with colorectal carcinoma. The outcomes were analyzed in relation to clinical-pathological data. CD163 expression was positive in cancer cells in 20 % of colorectal cancer patients and was related to advanced tumor stages (P = 0.008) and unfavorable prognosis (p = 0.001). High macrophage infiltration was related to shorter survival and positive CD163 expression in tumor cells. The prognostic impact of macrophage infiltration was independent of tumor stage and CD163 expression in cancer cells (p = 0.034). The expression of macrophage phenotype in colorectal cancer cells is associated with macrophage density in tumor stroma and lower survival rates. Macrophage infiltration has an independent prognostic impact on mortality in colorectal cancer. In accordance with previous experimental studies, these findings provide new insights into the role of macrophages in colorectal cancer.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4150873&blobtype=pdf
ISSN	18752292
Volume Number	7
DOI	10.1007/s12307-014-0145-7
PubMed Central reference number	PMC4150873
Issue Number	1-2
PubMed reference number	24771466
Journal	Cancer Microenvironment [Cancer Microenviron]
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-04-28
Publisher Place	Dordrecht
Access Restriction	Open
Rights License	© Springer Science+Business Media Dordrecht 2014
Subject Keyword	CD163 expression Macrophage infiltration Colorectal cancer
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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