Apparent diffusion coefficient evaluation for secondary changes in the cerebellum of rats after middle cerebral artery occlusion.

Content Provider	Europe PMC
Author	Yang, Yunjun Gao, Lingyun Fu, Jun Zhang, Jun Li, Yuxin Yin, Bo Chen, Weijian Geng, Daoying
Copyright Year	2013
Abstract	Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction core and remote regions after unilateral middle cerebral artery occlusion using apparent diffusion coefficient values. Diffusion-weighted imaging showed that the area of infarction core gradually increased to involve the cerebral cortex with increasing infarction time. Diffusion weighted imaging signals were initially increased and then stabilized by 24 hours. With increasing infarction time, the apparent diffusion coefficient value in the infarction core and remote bilateral cerebellum both gradually decreased, and then slightly increased 3–24 hours after infarction. Apparent diffusion coefficient values at remote regions (cerebellum) varied along with the change of supratentorial infarction core, suggesting that the phenomenon of diaschisis existed at the remote regions. Thus, apparent diffusion coefficient values and diffusion weighted imaging can be used to detect early diaschisis.
ISSN	16735374
Volume Number	8
PubMed Central reference number	PMC4146177
Issue Number	31
PubMed reference number	25206615
Journal	Neural Regeneration Research [Neural Regen Res]
e-ISSN	18767958
DOI	10.3969/j.issn.1673-5374.2013.31.007
Language	English
Publisher	Medknow Publications & Media Pvt Ltd
Publisher Date	2013-11-01
Publisher Place	India
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Neural Regeneration Research
Subject Keyword	neural regeneration brain injury cerebral ischemia cerebral infarction magnetic resonance imaging apparent diffusion coefficient middle cerebral artery occlusion diffusion weighted imaging infarction core remote regions diaschisis grants-supported paper neuroregeneration
Content Type	Text
Resource Type	Article
Subject	Developmental Neuroscience Neuroscience