NDLI: Diatomite silica nanoparticles for drug delivery.

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Diatomite silica nanoparticles for drug delivery.

Content Provider	Europe PMC
Author	Ruggiero, Immacolata Terracciano, Monica Martucci, Nicola M De Stefano, Luca Migliaccio, Nunzia Tatè, Rosarita Rendina, Ivo Arcari, Paolo Lamberti, Annalisa Rea, Ilaria
Copyright Year	2014
Abstract	Diatomite is a natural fossil material of sedimentary origin, constituted by fragments of diatom siliceous skeletons. In this preliminary work, the properties of diatomite nanoparticles as potential system for the delivery of drugs in cancer cells were exploited. A purification procedure, based on thermal treatments in strong acid solutions, was used to remove inorganic and organic impurities from diatomite and to make them a safe material for medical applications. The micrometric diatomite powder was reduced in nanoparticles by mechanical crushing, sonication, and filtering. Morphological analysis performed by dynamic light scattering and transmission electron microscopy reveals a particles size included between 100 and 300 nm. Diatomite nanoparticles were functionalized by 3-aminopropyltriethoxysilane and labeled by tetramethylrhodamine isothiocyanate. Different concentrations of chemically modified nanoparticles were incubated with cancer cells and confocal microscopy was performed. Imaging analysis showed an efficient cellular uptake and homogeneous distribution of nanoparticles in cytoplasm and nucleus, thus suggesting their potentiality as nanocarriers for drug delivery.PACS87.85.J81.05.Rm; 61.46. + w
ISSN	19317573
Journal	Nanoscale Research Letters
Volume Number	9
PubMed Central reference number	PMC4090628
Issue Number	1
PubMed reference number	25024689
e-ISSN	1556276X
DOI	10.1186/1556-276x-9-329
Language	English
Publisher	Springer
Publisher Date	2014-07-03
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. Copyright © 2014 Ruggiero et al.; licensee Springer.
Subject Keyword	Diatomite Porous silica nanoparticle Drug delivery system Surface modification
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Condensed Matter Physics Materials Science

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