Antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models.

Content Provider	Europe PMC
Author	Hajhashemi, Valiollah Klooshani, Vahid
Abstract	Objective: This study was aimed to examine the antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models. Materials and Methods: Hydroalcoholic extract of the plant leaves was prepared by percolation method. Male Swiss mice (25-35 g) and male Wistar rats (180-200 g) were randomly distributed in control, standard drug, and three experimental groups (n=6 in each group). Acetic acid-induced writhing, formalin test, and carrageenan-induced paw edema were used to assess the antinociceptive and anti-inflammatory effects. Results: The extract dose-dependently reduced acetic acid-induced abdominal twitches. In formalin test, the extract at any of applied doses (100, 200, and 400 mg/kg) could not suppress the licking behavior of first phase while doses of 200 and 400 mg/kg significantly inhibited the second phase of formalin test. In carrageenan test, the extract at a dose of 400 mg/kg significantly inhibited the paw edema by 26%. Conclusion: The results confirm the folkloric use of the plant extract in painful and inflammatory conditions. Further studies are needed to characterize the active constituents and the mechanism of action of the plant extract.
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ISSN	22287930
Journal	Avicenna Journal of Phytomedicine [Avicenna J Phytomed]
Volume Number	3
PubMed Central reference number	PMC4075706
Issue Number	2
PubMed reference number	25050274
e-ISSN	22287949
Language	English
Publisher	Mashhad University of Medical Sciences
Publisher Date	2013-01-01
Publisher Place	Mashhad, Iran
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2013: Avicenna Journal of Phytomedicine
Subject Keyword	Anti-inflammatory Antinociceptive Extract Urtica dioica
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Complementary and Alternative Medicine