Identification of microRNAs as potential biomarker for gastric cancer by system biological analysis.

Content Provider	Europe PMC
Author	Yan, Wenying Wang, Shouli Sun, Zhandong Lin, Yuxin Sun, Shengwei Chen, Jiajia Chen, Weichang
Copyright Year	2014
Abstract	Gastric cancers (GC) have the high morbidity and mortality rates worldwide and there is a need to identify sufficiently sensitive biomarkers for GC. MicroRNAs (miRNAs) could be promising potential biomarkers for GC diagnosis. We employed a systematic and integrative bioinformatics framework to identify GC-related microRNAs from the public microRNA and mRNA expression dataset generated by RNA-seq technology. The performance of the 17 candidate miRNAs was evaluated by hierarchal clustering, ROC analysis, and literature mining. Fourteen have been found to be associated with GC and three microRNAs (miR-211, let-7b, and miR-708) were for the first time reported to associate with GC and may be used for diagnostic biomarkers for GC.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2014
PubMed Central reference number	PMC4058523
PubMed reference number	24982912
e-ISSN	23146141
DOI	10.1155/2014/901428
Language	English
Publisher	Hindawi
Publisher Date	2014-05-28
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2014 Wenying Yan et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology