NDLI: Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer.

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Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer.

Content Provider	Europe PMC
Author	Cihoric, N Savic, S Schneider, S Ackermann, I Bichsel-Naef, M Schmid, R A Lardinois, D Gugger, M Bubendorf, L Zlobec, I Tapia, C
Copyright Year	2014
Abstract	Background:Recently, fibroblast growth factor receptor 1 (FGFR1) was discovered in squamous cell carcinomas (SCC) of the lung with FGFR1 amplification described as a promising predictive marker for anti-FGFR inhibitor treatment. Only few data are available regarding prevalence, prognostic significance and clinico-pathological characteristics of FGFR1-amplified and early-stage non-small cell lung carcinomas (NSCLC). We therefore investigated the FGFR1 gene status in a large number of well-characterised early-stage NSCLC.Methods:FGFR1 gene status was evaluated using a commercially available fluorescent in situ hybridisation (FISH) probe on a tissue microarray (TMA). This TMA harbours 329 resected, formalin-fixed and paraffin-embedded, nodal-negative NSCLC with a UICC stage I–II. The FISH results were correlated with clinico-pathological features and overall survival (OS).Results:The prevalence of an FGFR1 amplification was 12.5% (41/329) and was significantly (P<0.0001) higher in squamous cell carcinoma (SCC) (20.7%) than in adenocarcinoma (2.2%) and large cell carcinoma (13%). Multivariate analysis revealed significantly (P=0.0367) worse 5-year OS in patients with an FGFR1-amplified NSCLC.Conclusions:FGFR1 amplification is common in early-stage SCC of the lung and is an independent and adverse prognostic marker. Its potential role as a predictive marker for targeted therapies or adjuvant treatment needs further investigation.
ISSN	00070920
Journal	British Journal of Cancer
Volume Number	110
PubMed Central reference number	PMC4056052
Issue Number	12
PubMed reference number	24853178
e-ISSN	15321827
DOI	10.1038/bjc.2014.229
Language	English
Publisher	Nature Publishing Group
Publisher Date	2014-05-22
Access Restriction	Open
Rights License	From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ Copyright © 2014 Cancer Research UK
Subject Keyword	NSCLC squamous cell carcinoma FGFR1 prognosis amplification fluorescence in situ hybridisation
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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