Prognostic Significance of Metabolic Tumor Volume Measured by (18)F-FDG PET/CT in Operable Primary Breast Cancer.

Content Provider	Europe PMC
Author	Kim, Jahae Yoo, Su Woong Kang, Sae-Ryung Cho, Sang-Geon Oh, Jong-Ryool Chong, Ari Min, Jung-Joon Bom, Hee-Seung Yoon, Jung-Han Song, Ho-Chun
Abstract	Purpose We investigated whether PET indices measured by 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can predict prognosis in patients with operable primary breast cancer. Methods We reviewed 53 patients with operable primary breast cancer who underwent pretreatment FDG PET/CT. PET indices, maximum standardized uptake value (SUV) and metabolic tumor volume (MTV), were measured in the primary breast tumor (P), metastatic lymph nodes (N) and total tumor (T). The Cox proportional hazards model was used with age, tumor size, clinical lymph node status, method of surgery, presence or absence of neoadjuvant chemotherapy, histological type, histological grade, hormone receptors and HER2 status to predict disease-free survival (DFS) and overall survival (OS). Results Median follow-up period was 50 months (range, 17–73 months), during which 17 patients had recurrent disease and nine of whom died. The univariate analysis showed that high SUV of N (NSUV, P = 0.011), MTV of N (NMTV, P = 0.011) and MTV of T (TMTV, P = 0.045) as well as high histological grade (P = 0.008), negative estrogen (P = 0.045) and negative progesterone (P = 0.029) receptor status were associated with shorter DFS. High NSUV (P = 0.035), NMTV (P = 0.035) and TMTV (P = 0.035) as well as high histological grade (P = 0.012) and negative estrogen receptor status (P = 0.009) were associated with shorter OS. NSUV, NMTV and TMTV were found to be significantly associated with high histological grade (P = 0.005). However, those failed to be statistically significant prognostic factors on multivariate analysis. Conclusions PET indices seem to be useful in the preoperative evaluation of prognosis in patients with operable primary breast cancer. NSUV, NMTV and TMTV might be considerable factors associated with patient outcome in operable breast cancer.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4043062&blobtype=pdf
ISSN	18693474
Volume Number	46
DOI	10.1007/s13139-012-0161-9
PubMed Central reference number	PMC4043062
Issue Number	4
PubMed reference number	24900075
Journal	Nuclear Medicine and Molecular Imaging [Nucl Med Mol Imaging]
e-ISSN	18693482
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-08-25
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	© Korean Society of Nuclear Medicine 2012
Subject Keyword	Breast cancer FDG PET/CT Maximum standardized uptake value Metabolic tumor volume Prognosis
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging