Recent Trends in the Nucleophilic [(18)F]-radiolabeling Method with No-carrier-added [(18)F]fluoride.

Content Provider	Europe PMC
Author	Kim, Dong Wook Jeong, Hwan-Jeong Lim, Seok Tae Sohn, Myung-Hee
Abstract	Noninvasive imaging in living subjects with positron emission tomography (PET) provides early detection of diseases in humans. For this application, it is necessary to prepare specific molecular imaging probes labeled with positron-emitting radioisotopes such as fluorine-18 for obtaining high-quality PET imaging. In this review, we describe recent trends in the F-18 radiolabeling method for the introduction of no-carrier-added fluorine-18, which was obtained from an 18O(p,n)18F reaction, into a specific molecular site, which in turn is intended to serve as an imaging agent for PET study. These labeling protocols are based on ionic liquid media 18F radiofluorination in the presence of some water, enzymatic 18F fluorination using fluorinase in water solution, non-polar protic alcohol media 18F radiofluorination and its mechanism, and nucleophilic 18F fluorination of an aromatic iodonium salt precursor.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4042963&blobtype=pdf
ISSN	18693474
Volume Number	44
DOI	10.1007/s13139-009-0008-1
PubMed Central reference number	PMC4042963
Issue Number	1
PubMed reference number	24899934
Journal	Nuclear Medicine and Molecular Imaging [Nucl Med Mol Imaging]
e-ISSN	18693482
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-02-26
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	© Korean Society of Nuclear Medicine 2010
Subject Keyword	Nucleophilic fluorination Fluorine-18 Ionic liquid Tert alcohol Fluorinase Iodonium salts
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging