Surveillance of ESBL producing multidrug resistant Escherichia coli in a teaching hospital in India

Content Provider	Europe PMC
Author	Rath, Shakti Dubey, Debasmita Sahu, Mahesh C. Padhy, Rabindra N
Copyright Year	2014
Abstract	Objective To record nosocomial and community-acquired accounts of antibiotic resistance in Escherichia coli (E. coli) strains, isolated from clinical samples of a teaching hospital by surveillance, over a period of 39 months (November 2009-January 2013). Methods Clinical samples from nosocomial sources, i.e., wards and cabins, intensive care unit (ICU) and neonatal intensive care unit (NICU), and community (outpatient department, OPD) sources of the hospital, were used for isolating strains of E. coli, which were subjected for testing for production of ‘extended spectrum beta-lactamase’-(ESBL) enzyme as well as determining antibiotic sensitivity pattern with 23 antibiotics. Results Of the total 1642 (100%) isolates, 810 (49.33%) strains were from OPD and 832 (50.66%) were from hospital settings. Occurrence of infectious E. coli strains increased in a mathematical progression in community sources, but in nosocomial infections, such values remained almost constant in each quarter. A total of 395 (24.05%) ESBL strains were isolated from the total 810 isolates of community; of the total of 464 (28.25%) isolates of wards and cabins, 199 (12.11%) were ESBL strains; and among the total of 368 (22.41%) isolates of ICU and NICU, ESBLs were 170 (10.35%); the total nosocomial ESBL isolates, 369 (22.47%) were from the nosocomial total of 832 (50.66%) isolates. Statistically, it was confirmed that ESBL strains were equally distributed in community or hospital units. Antibiogram of 23 antibiotics revealed progressive increases of drug-resistance against each antibiotic with the maximum resistance values were recorded against gentamicin: 92% and 79%, oxacillin: 94% and 69%, ceftriaxone: 85% and 58%, and norfloxacin 97% and 69% resistance, in nosocomial and community isolates, respectively. Conclusions This study revealed the daunting state of occurrence of multidrug resistant E. coli and its infection dynamics in both community and hospital settings.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4032044&blobtype=pdf
ISSN	22221808
Volume Number	4
PubMed Central reference number	PMC4032044
Issue Number	2
PubMed reference number	PMC4032044
Journal	Asian Pacific Journal of Tropical Disease [Asian Pac J Trop Dis]
e-ISSN	22221808
DOI	10.1016/s2222-1808(14)60331-5
Language	English
Publisher	Asian Pacific Tropical Medicine Press
Publisher Date	2014-04-01
Access Restriction	Open
Rights License	© 2014 by the Asian Pacific Journal of Tropical Disease. All rights reserved.
Subject Keyword	E. coli Nosocomial ESBL strains Multidrug-resistance Community Infection dynamics
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)