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Association of the PPAR-γ Gene with Altered Glucose Levels and Psychosis Profile in Schizophrenia Patients Exposed to Antipsychotics.
| Content Provider | Europe PMC |
|---|---|
| Author | Liu, Yun-Ru Hu, Tsung-Ming Lan, Tsuo-Hung Chiu, Hsien-Jane Chang, Yung-Han Chen, Shuo-Fei Yu, Yen-Hsin Chen, Cheng-Chung Loh, El-Wui |
| Copyright Year | 2014 |
| Abstract | ObjectiveMetabolic abnormalities, e.g., diabetes, are common among schizophrenia patients. Peroxisome proliferator activated receptor-γ (PPAR-γ) regulates glucose/lipid metabolisms, and schizophrenia like syndrome may be induced by actions involving retinoid X receptor-α/PPAR-γ heterodimers. We examined a possible role of the PPAR-γ gene in metabolic traits and psychosis profile in schizophrenia patients exposed to antipsychotics.MethodsSingle nucleotide polymorphisms (SNPs) of the PPAR-γ gene and a serial of metabolic traits were determined in 394 schizophrenia patients, among which 372 were rated with Positive and Negative Syndrome Scale (PANSS).ResultsSNP-10, -12, -18, -19, -20 and -26 were associated with glycated hemoglobin (HbA1c) whereas SNP-18, -19, -20 and -26 were associated with fasting plasma glucose (FPG). While SNP-23 was associated with triglycerides, no associations were identified between the other SNPs and lipids. Further haplotype analysis demonstrated an association between the PPAR-γ gene and psychosis profile.ConclusionOur study suggests a role of the PPAR-γ gene in altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics. Although the Pro12Ala at exon B has been concerned an essential variant in the development of obesity, the lack of association of the variant with metabolic traits in this study should not be treated as impossibility or a proof of error because other factors, e.g., genes regulated by PPAR-γ, may have complicated the development of metabolic abnormalities. Whether the PPAR-γ gene modifies the risk of metabolic abnormalities or psychosis, or causes metabolic abnormalities that lead to psychosis, remains to be examined. |
| ISSN | 17383684 |
| Journal | Psychiatry Investigation |
| Volume Number | 11 |
| PubMed Central reference number | PMC4023093 |
| Issue Number | 2 |
| PubMed reference number | 24843374 |
| e-ISSN | 19763026 |
| DOI | 10.4306/pi.2014.11.2.179 |
| Language | English |
| Publisher | Korean Neuropsychiatric Association |
| Publisher Date | 2014-04-11 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2014 Korean Neuropsychiatric Association |
| Subject Keyword | Schizophrenia Psychosis Glucose PPAR-γ gene |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Psychiatry and Mental Health |
