Prevalence of Anti-deamidated Gliadin Peptide Antibodies in Asian Patients With Irritable Bowel Syndrome.

Content Provider	Europe PMC
Author	Lu, Wei Gwee, Kok-Ann Siah, Kewin Tien Ho Kang, Jin Yong Lee, Rumin Ngan, Cecilia Cheng Lai
Copyright Year	2014
Abstract	Background/AimsNon-celiac gluten sensitivity has been increasingly recognized as a predisposing factor for irritable bowel syndrome (IBS)-like symptoms in Western populations where celiac disease (CD) is relatively common. In Asia where CD is rare, we wish to determine the prevalence of gluten protein associated serology in IBS patients, which has not been formally studied, and its relation to histological and human leukocyte antigen (HLA) markers.MethodsWe reviewed a consecutive cohort of Asian patients with IBS, who had undergone serologic testing for IgA against deamidated gliadin peptide antibodies (IgA DGP) and IgA anti-endomysium antibodies, and who also had duodenal biopsies during clinical workup. In addition, a subset of Chinese patients with positive serology was further tested for HLA-DQ2 and HLA-DQ8.ResultsOf 186 patients, 34 (18%) were positive for IgA DGP; bloating, abdominal pain, belching and diarrhea were the most commonly reported symptoms but diarrhea as the most bothersome symptom was significantly more common in IgA DGP positive patients. Mildly increased intra-epithelial lymphocytes on duodenal biopsy was also more common (29% vs. 9%, P = 0.001). Nine of 21 Chinese patients tested as IgA DGP positive undertook HLA-DQ2/DQ8 testing, with only 2 being positive for HLA-DQ8. All patients with positive IgA DGP reported symptom improvement with gluten withdrawal.ConclusionsWe have described a series of Asian, mainly Chinese, patients with IBS who were tested positive for IgA DGP, and improved on a gluten exclusion diet. We believe this is the first report of non-celiac gluten sensitivity in Asia, a region where CD is uncommon.
ISSN	20930879
Journal	Journal of Neurogastroenterology and Motility
Volume Number	20
PubMed Central reference number	PMC4015193
Issue Number	2
PubMed reference number	24840376
e-ISSN	20930887
DOI	10.5056/jnm.2014.20.2.236
Language	English
Publisher	Korean Society of Neurogastroenterology and Motility
Publisher Date	2014-04-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2014 The Korean Society of Neurogastroenterology and Motility
Subject Keyword	Asian Celiac disease Gliadin Gluten sensitive enteropathy Irritable bowel syndrome
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Gastroenterology