NDLI: Interleukin-1α -899 (+4845) C→T polymorphism is not associated with aggressive periodontitis susceptibility: A meta-analysis based on 19 case-control studies.

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Interleukin-1α -899 (+4845) C→T polymorphism is not associated with aggressive periodontitis susceptibility: A meta-analysis based on 19 case-control studies.

Content Provider	Europe PMC
Author	WANG, WAN-FEN SHI, JUN CHEN, SHAO-JUAN NIU, YU-MING ZENG, XIAN-TAO
Copyright Year	2014
Abstract	A number of published studies investigated the association between interleukin-1α (IL-1α) −899 (+4845) C→T polymorphism and susceptibility to aggressive periodontitis (AgP). However, the results from different studies are controversial. This study was conducted to further investigate the association between IL-1α −899 (+4845) C→T polymorphism and AgP using a meta-analysis. A search was conducted through PubMed up to May 1, 2013 and a total of 19 relevant case-control studies were identified. The results of this meta-analysis demonstrated that IL-1α −899 (+4845) C→T polymorphism is not associated with susceptibility to AgP under allele T vs. C [odds ratio (OR)=1.00, 95% confidence interval (CI): 0.88–1.14, P=0.98; I2=28.86%] or allele A vs. C comparison (OR=0.99, 95% CI: 0.85–1.14, P=0.85; I2=33.66%). The subgroup analyses based on ethnicity, source of controls and Hardy-Weinberg equilibrium (HWE) also revealed no such association. There existed a weak publication bias (Egger’s test P=0.02). In conclusion, based on the currently available evidence, there is no association between IL-1α −899 (+4845) C→T polymorphism and susceptibility to AgP.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3990208&blobtype=pdf
ISSN	20499434
Journal	Biomedical Reports [Biomed Rep]
Volume Number	2
DOI	10.3892/br.2014.240
PubMed Central reference number	PMC3990208
Issue Number	3
PubMed reference number	24748978
e-ISSN	20499442
Language	English
Publisher	D.A. Spandidos
Publisher Date	2014-02-19
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2014, Spandidos Publications
Subject Keyword	aggressive periodontitis susceptibility interleukin-1α polymorphism meta-analysis
Content Type	Text
Resource Type	Article
Subject	Neuroscience Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

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