NDLI: Anti-inflammatory activity of mirabilis jalapa linn. Leaves.

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Anti-inflammatory activity of mirabilis jalapa linn. Leaves.

Content Provider	Europe PMC
Author	Nath, Lekshmi. R. Manjunath, K. P. Savadi, R. V. Akki, K. S.
Copyright Year	2010
Abstract	Mirabilis Jalapa Linn. is a widely used traditional medicine in many parts of the world for the treatment of various diseases viz. virus inhibitory activity, anti tumour activity. It is claimed in traditional medicine that the leaves of the plant are used in the treatment of inflammation. In the present study, the total alcoholic extract and successive petroleum ether fractions of leaves of Mirabilis Jalapa Linn were screened for its anti-inflammatory activity using carageenan induced rat paw edema and cotton pellet induced granuloma models. The total alcoholic extract at the dose of 300 mg/kg p.o and successive petroleum ether fraction at the dose of 200 mg/kg exhibited significant anti-inflammatory activity in carrageenan induced paw edema model (p<0.01). In cotton pellet granuloma model, the total alcoholic extract at the dose of 300 mg/kg and successive petroleum ether fraction at the dose of 200 mg/kg inhibited granuloma formation significantly (p<0.05) indicating that both test samples inhibit the increase in number of fibroblasts and synthesis of collagen and mucopolysaccharides during granuloma tissue formation during the chronic inflammation. These experimental results have established a pharmacological evidence for the folklore claim of the drug to be used as an anti inflammatory agent.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3979185&blobtype=pdf
ISSN	09760105
Journal	Journal of Basic and Clinical Pharmacy [J Basic Clin Pharm]
Volume Number	1
PubMed Central reference number	PMC3979185
Issue Number	2
PubMed reference number	24825972
e-ISSN	09760113
Language	English
Publisher	Medknow Publications & Media Pvt Ltd
Publisher Date	2010-03-01
Publisher Place	India
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Journal of Basic and Clinical Pharmacy
Subject Keyword	Anti inflammatory Mirabilis Jalapa Traditional Medicine
Content Type	Text
Resource Type	Article
Subject	Pharmacy

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