Risk factors for intestinal metaplasia in concomitant gastric and duodenal ulcer disease.

Content Provider	Europe PMC
Author	HONG, JUN-BO XIA, LIANG ZUO, WEI WANG, AN-JIANG XU, SHAN XIONG, HUI-FANG CHEN, YOU-XIANG ZHU, XUAN LU, NONG-HUA
Copyright Year	2014
Abstract	The aim of this study was to estimate the prevalence and risk factors of intestinal metaplasia (IM) in concomitant gastric and duodenal ulcer (CGDU) disease by retrospectively reviewing consecutive patients who had undergone esophagogastroduodenal endoscopy. Patients who received the endoscopic diagnosis of CGDU disease were selected for analysis and the recorded demographic, endoscopic, clinical and outcome data, including data on the development of IM, were extracted. Associations of the various parameters with IM were estimated by logistic regression analysis and described by the odds ratio (OR) with a 95% confidence interval (CI). Among the total 204,073 consecutive patients screened, 2,397 (1.2%) were diagnosed with CGDU disease. Following application of the exclusion criteria, a total of 2,149 cases were included in the study. The IM prevalence was 8.4%, represented by 153 mild cases, 26 moderate cases and one severe case. Multivariate analysis identified age ≥50 years (OR=2.606, 95% CI=1.889–3.597, χ2=34.000, P<0.001), ulcer at the gastric incisura (OR=2.644, 95% CI=1.926–3.630, χ2=36.142, P<0.001) and Helicobacter pylori (H. pylori) infection (OR=2.338, 95% CI=1.573–3.474, χ2=17.648, P<0.001) as independent risk factors for the development of IM. In addition, the moderate and severe IM grades were more frequently detected in males than in females (18.8% vs. 5.8%; OR=3.769, 95% CI=1.083–13.121, χ2=4.887, P=0.036). IM in patients with CGDU disease is not uncommon. CGDU patients with ongoing H. pylori infection, gastric incisura involvement, older age and/or male gender may be at a higher risk of IM.
ISSN	17920981
Journal	Experimental and Therapeutic Medicine
Volume Number	7
PubMed Central reference number	PMC3964929
Issue Number	4
PubMed reference number	24669253
e-ISSN	17921015
DOI	10.3892/etm.2014.1507
Language	English
Publisher	D.A. Spandidos
Publisher Date	2014-01-28
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2014, Spandidos Publications
Subject Keyword	Helicobacter pylori infection risk factors concomitant gastric and duodenal ulcers intestinal metaplasia
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Cancer Research