NDLI: Neuroendocrine differentiation in prostate adenocarcinoma biopsies and its correlation to histological grading.

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Neuroendocrine differentiation in prostate adenocarcinoma biopsies and its correlation to histological grading.

Content Provider	Europe PMC
Author	Marcu, Mădălina Radu, E. Sajin, Maria
Copyright Year	2010
Abstract	Prostate adenocarcinoma is frequently diagnosed on needle biopsies in early, organ-confined stages. New prognostic factors would help identifying at this stage patients at risk for unfavorable evolution, that would benefit from alternate therapy. This study aims to find correlations between the extent of neurocrine differentiation (NED), a feature commonly seen in prostate carcinoma, and known factors of disease evolution such as histological grade, malignant cell proliferation and serum PSA levels. Immunohistochemistry for choromogranin A and neuron-specific enaolase (NSE) was used to calculate expression scores in order to asses the extent of NED in prostate biopsies. Tumour proliferative activity was estimated by calculating percentages of Ki-67 immunoreactive cell nuclei. Results show that the presence of numerous clusters of chromogranin A positive cells is a feature that differentiate tumours with Gleason score 9 from those with a score of 6. Also, the same extended neuroendocrine differentiation is associated with high tumour proliferative activity. Multinomial regression analysis showed that high Ki indices, serum PSA values and NSE scores are predictive for moderately and poorly differentiated prostatic adenocarcinoma.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3945267&blobtype=pdf
ISSN	20670656
Journal	Current Health Sciences Journal [Curr Health Sci J]
Volume Number	36
PubMed Central reference number	PMC3945267
Issue Number	1
PubMed reference number	24778825
e-ISSN	20694032
Language	English
Publisher	Medical University Publishing House Craiova
Publisher Date	2010-01-01
Access Restriction	Open
Rights License	Copyright © 2010, Medical University Publishing House Craiova
Subject Keyword	Prostate adenocarcinoma Neuroendocrine differentiation
Content Type	Text
Resource Type	Article
Subject	Medicine

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