Autologous intravenous mononuclear stem cell therapy in chronic ischemic stroke.

Content Provider	Europe PMC
Author	Bhasin, A Srivastava, MV Bhatia, R Mohanty, S Kumaran, SS Bose, S
Copyright Year	2012
Abstract	Background: The regenerative potential of brain has led to emerging therapies that can cure clinico-motor deficits after neurological diseases. Bone marrow mononuclear cell therapy is a great hope to mankind as these cells are feasible, multipotent and aid in neurofunctional gains in Stroke patients. Aims: This study evaluates safety, feasibility and efficacy of autologous mononuclear (MNC) stem cell transplantation in patients with chronic ischemic stroke (CIS) using clinical scores and functional imaging (fMRI and DTI). Design: Non randomised controlled observational study Study: Twenty four (n=24) CIS patients were recruited with the inclusion criteria as: 3 months-2years of stroke onset, hand muscle power (MRC grade) at least 2; Brunnstrom stage of recovery: II-IV; NIHSS of 4-15, comprehendible. Fugl Meyer, modified Barthel Index (mBI) and functional imaging parameters were used for assessment at baseline, 8 weeks and at 24 weeks. Twelve patients were administered with mean 54.6 million cells intravenously followed by 8 weeks of physiotherapy. Twelve patients served as controls. All patients were followed up at 24 weeks. Outcomes: The laboratory and radiological outcome measures were within normal limits in MNC group. Only mBI showed statistically significant improvement at 24 weeks (p<0.05) whereas the mean FM, MRC, Ashworth tone scores in the MNC group were high as compared to control group. There was an increased number of cluster activation of Brodmann areas BA 4, BA 6 post stem cell infusion compared to controls indicating neural plasticity. Cell therapy is safe and feasible which may facilitate restoration of function in CIS.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3908296&blobtype=pdf
Page Count	9
Volume Number	8
PubMed Central reference number	PMC3908296
Issue Number	3
PubMed reference number	24693196
Journal	Journal of Stem Cells & Regenerative Medicine [J Stem Cells Regen Med]
e-ISSN	09737154
Language	English
Publisher	Journal of Stem Cells and Regenerative Medicine
Publisher Date	2012-11-26
Access Restriction	Open
Rights License	This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2012 Journal of Stem Cells and Regenerative Medicine
Subject Keyword	Cell transplantation Stroke Mononuclear Stem Cells Functional Recovery Neuroimaging
Content Type	Text
Resource Type	Article
Subject	Biochemistry Cell Biology Molecular Biology Biotechnology