NDLI: Serum urea:albumin ratio as a prognostic marker in critical patients with non-chronic kidney disease.

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Serum urea:albumin ratio as a prognostic marker in critical patients with non-chronic kidney disease.

Content Provider	Europe PMC
Author	Gundpatil, D. B. Somani, B. L. Saha, T. K. Banerjee, M.
Abstract	Routine laboratory investigations play an important role in estimating the risk of mortality in intensive care unit (ICU) patients. The significance of urea:albumin ratio (UAR) in predicting the stay and mortality of ICU patients is not known. It is a retrospective study of patients admitted to ICU (n = 412) with non-chronic kidney disease (non-CKD). Receiver-operating characteristics (ROC) analysis for predicting mortality was carried out to find area under curve (AUC) and threshold levels. Analysis of survival probability was carried out by Kaplan–Meier method and Log-rank test. The AUC to predict mortality were 0.695, 0.767 and 0.791 for serum albumin, urea and UAR, respectively. The threshold levels for albumin, urea and UAR were 2.8 g/dL, 53 mg/dL, and 23.44 mg/g, respectively. The highest odds ratio (OR) of 9.75 to predict mortality at threshold level was observed for UAR, while OR were 7.0 and 3.62 for serum urea and albumin, respectively. The serum urea above and albumin below threshold level were associated with increase in ICU stay of >3 days but the highest OR of 4.73 to predict stay of >3 days was observed for UAR. Kaplan–Meier survival analysis shows significant (p < 0.001) difference at the threshold value of UAR. Serum urea and albumin are found to be an independent predictor for the mortality and stay; however an increased UAR value is the best parameter in predicting mortality and stay in ICU patients with non-CKD illness.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3903933&blobtype=pdf
ISSN	09701915
Volume Number	29
DOI	10.1007/s12291-012-0274-z
PubMed Central reference number	PMC3903933
Issue Number	1
PubMed reference number	24478558
Journal	Indian Journal of Clinical Biochemistry [Indian J Clin Biochem]
e-ISSN	09740422
Language	English
Publisher	Springer India
Publisher Date	2012-11-07
Publisher Place	India
Access Restriction	Open
Rights License	© Association of Clinical Biochemists of India 2012
Subject Keyword	Urea:albumin ratio (UAR) Critical patients Non-CKD Stay Mortality Threshold level
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry

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