Effects of Carum carvi L. (Caraway) extract and essential oil on TNBS-induced colitis in rats.

Content Provider	Europe PMC
Author	Keshavarz, A. Minaiyan, M. Ghannadi, A. Mahzouni, P.
Copyright Year	2013
Abstract	Carum carvi L. (Apiaceae family) or caraway is a common household plant grown around the world including Iran. Caraway fruits are used as flavoring agent in foods and beverages, and have various traditional uses in ethnomedicine. Anti-inflammatory, spasmolytic, antimicrobial, antioxidant, carminative and immunomodulatory properties of caraway suggest that it might exert beneficial effects on inflammatory bowel disease (IBD). Therefore, this study was carried out to investigate the effects of caraway hydroalcoholic extract (CHE) and its essential oil (CEO) in an immunological model of colitis in rats induced by trinitrobenzene sulfonic acid (TNBS). Different doses of CHE (100, 200, 400 mg/kg) and CEO (100, 200, 400 μl/kg) were administered orally (p.o.) and also doses of CHE (100, 400 mg/kg) and CEO (100, 400 μl/kg) were given intraperitoneally (i.p.) to the separate groups of male Wistar rats (n=6). Administration of the doses started 6 h after induction of colitis and continued daily for 5 consecutive days. Wet colon weight/length ratio was measured and tissue damage scores as well as indices of colitis were evaluated both macroscopically and histopathologically. CHE and CEO at all doses tested were effective in reducing colon tissue lesions and colitis indices and the efficacy was nearly the same when different doses of plant fractions were administered p.o. or i.p. Administration of prednisolone (p.o., 4 mg/kg), Asacol® (mesalazine microgranules, p.o., 100 mg/kg) and hydrocortisone acetate (i.p., 20 mg/kg) as references were effective in reducing colon tissue injures as well. These data suggest that caraway fractions are both effective and possess anti-colitic activity irrespective of the dose and route of administration.
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ISSN	17355362
Journal	Research in Pharmaceutical Sciences [Res Pharm Sci]
Volume Number	8
PubMed Central reference number	PMC3895295
Issue Number	1
PubMed reference number	24459470
e-ISSN	17359414
Language	English
Publisher	Medknow Publications & Media Pvt Ltd
Publisher Date	2013-01-01
Publisher Place	India
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Journal of Research in Pharmaceutical Sciences
Subject Keyword	Colitis Carum carvi L. Hydroalcoholic extract Essential oil Trinitrobenzene sulfonic acid (TNBS) Rats
Content Type	Text
Resource Type	Article
Subject	Pharmacology, Toxicology and Pharmaceutics