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Hepatic Fibrosis Inhibitory Effect of Peptides Isolated from Navicula incerta on TGF-β1 Induced Activation of LX-2 Human Hepatic Stellate Cells.
| Content Provider | Europe PMC |
|---|---|
| Author | Kang, Kyong-Hwa Qian, Zhong-Ji Ryu, BoMi Karadeniz, Fatih Kim, Daekyung Kim, Se-Kwon |
| Copyright Year | 2013 |
| Abstract | In this study, novel peptides (NIPP-1, NIPP-2) derived from Navicula incerta (microalgae) protein hydrolysate were explored for their inhibitory effects on collagen release in hepatic fibrosis with the investigation of its underlying mechanism of action. TGF-β1 activated fibrosis in LX-2 cells was examined in the presence or absence of purified peptides NIPP-1 and NIPP-2. Besides the mechanisms of liver cell injury, protective effects of NIPP-1 and NIPP-2 were studied to show the protective mechanism against TGF-β1 stimulated fibrogenesis. Our results showed that the core protein of NIPP-1 peptide prevented fibril formation of type I collagen, elevated the MMP level and inhibited TIMP production in a dose-dependent manner. The treatment of NIPP-1 and NIPP-2 on TGF-β1 induced LX-2 cells alleviated hepatic fibrosis. Moreover, α-SMA, TIMPs, collagen and PDGF in the NIPP-1 treated groups were significantly decreased. Therefore, it could be suggested that NIPP-1 has potential to be used in anti-fibrosis treatment. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3892505&blobtype=pdf |
| ISSN | 22871098 |
| Journal | Preventive Nutrition and Food Science [Prev Nutr Food Sci] |
| Volume Number | 18 |
| DOI | 10.3746/pnf.2013.18.2.124 |
| PubMed Central reference number | PMC3892505 |
| Issue Number | 2 |
| PubMed reference number | 24471121 |
| e-ISSN | 22878602 |
| Language | English |
| Publisher | The Korean Society of Food Science and Nutrition |
| Publisher Date | 2013-06-01 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2013 by The Korean Society of Food Science and Nutrition. All rights Reserved. |
| Subject Keyword | microalgae hepatic stellate cells hepatic fibrosis LX-2 liver injury |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Food Science |
