NDLI: Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold.

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Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold.

Content Provider	Europe PMC
Author	Im, Jin-Young Min, Woo-Kie You, Changkook Kim, Hyun-Ok Jin, Hee-Kyung Bae, Jae-sung
Copyright Year	2013
Abstract	Combination of tissue engineering and cell therapy represents a promising approach for bone regeneration. Human mesenchymal stem cells (hMSCs) have properties that include low immunogenicity, high proliferation rate, and multi-differentiation potential; therefore, they are an attractive seeding source for tissue engineering therapy. Here we found that hMSCs with a scaffold did not affect cell viability and osteogenic differentiation. We also investigated regenerative effect of hMSCs with the scaffold in a calvarial bone defect model. Formation of new bone was evaluated by micro-CT, histology and expression of osteogenic markers. The results clearly showed interesting evidence indicating that hMSCs with scaffold increased the formation of new bone and expression of osteogenic markers, compared to the empty and scaffold only groups. Overall, our results suggest that hMSCs with scaffold are suitable for stimulation of intense bone regeneration in critical-sized bone defects.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3879338&blobtype=pdf
ISSN	17386055
Journal	Laboratory Animal Research [Lab Anim Res]
Volume Number	29
DOI	10.5625/lar.2013.29.4.196
PubMed Central reference number	PMC3879338
Issue Number	4
PubMed reference number	24396384
e-ISSN	22337660
Language	English
Publisher	Korean Association for Laboratory Animal Science
Publisher Date	2013-12-20
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2013 Korean Association for Laboratory Animal Science
Subject Keyword	Human mesenchymal stem cells scaffold bone regeneration calvarial bone defect
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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