Hypogonadism and erectile dysfunction in myotonic dystrophy type 1.

Content Provider	Europe PMC
Author	PERIC, STOJAN NISIC, TANJA MILICEV, MILENA BASTA, IVANA MARJANOVIC, IVAN PERIC, MARINA LAVRNIC, DRAGANA RAKOCEVIC STOJANOVIC, VIDOSAVA
Abstract	Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults. It affects many organs and systems besides muscle. Aim of this study was to assess frequency of erectile dysfunction (ED) and hypogonadism, the correlation between them and the impact of ED on quality of life (QoL) in patients with DM1. A series of 25 men (aged from 22 to 58 years) with a diagnosis of DM1 was analyzed. Muscular Impairment Rating Scale (MIRS) was used to assess severity of muscular involvement. Erectile function was assessed using the short form of the International Index of Erectile Function test (IIEF-5). Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone were assessed. All patients completed the Serbian version of the SF-36 questionnaire as a measure of health-related QoL. ED was present in 18 (72%) of patients. Seven (28%) patients were euogonadic, 16 (64%) had compensated hypogonadism and 2 (8%) had primary hypogonadism. ED was somewhat more common in patients with hypogonadism (78% vs. 57%). Mental composite score of SF-36 was lower in patients with ED (p<0.05). Our results showed that 72% of men with DM1 had ED and hypogonadism. Studies with larger number of subjects are needed to resolve cascade of events that lays behind ED in DM1. Development of therapeutic strategies may have positive impact on QoL. Substitutive therapy with androgens may be benefitial.
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ISSN	11282460
Journal	Acta Myologica [Acta Myol]
Volume Number	32
PubMed Central reference number	PMC3866901
Issue Number	2
PubMed reference number	24399868
e-ISSN	11282460
Language	English
Publisher	Pacini Editore SpA
Publisher Date	2013-10-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/ The journal and the individual contributions contained in it are protected by the copyright of Gaetano Conte Academy, Naples, Italy
Subject Keyword	myotonic dystrophy type 1 erectile dysfunction hypogonadis
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine