ER stress upregulated PGE₂/IFNγ-induced IL-6 expression and down-regulated iNOS expression in glial cells.

Content Provider	Europe PMC
Author	Hosoi, Toru Honda, Miya Oba, Tatsuya Ozawa, Koichiro
Copyright Year	2013
Abstract	The disruption of endoplasmic reticulum (ER) function can lead to neurodegenerative disorders, in which inflammation has also been implicated. We investigated the possible correlation between ER stress and immune function using glial cells. We demonstrated that ER stress synergistically enhanced prostaglandin (PG) E₂ + interferon (IFN) γ-induced interleukin (IL)-6 production. This effect was mediated through cAMP. Immune-activated glial cells produced inducible nitric oxide synthase (iNOS). Interestingly, ER stress inhibited PGE₂ + IFNγ-induced iNOS expression. Similar results were obtained when cells were treated with dbcAMP + IFNγ. Thus, cAMP has a dual effect on immune reactions; cAMP up-regulated IL-6 expression, but down-regulated iNOS expression under ER stress. Therefore, our results suggest a link between ER stress and immune reactions in neurodegenerative diseases.
Journal	Scientific Reports [Sci Rep]
Volume Number	3
DOI	10.1038/srep03388
PubMed Central reference number	PMC3844943
PubMed reference number	24291824
e-ISSN	20452322
Language	English
Publisher	Nature Publishing Group
Publisher Date	2013-12-02
Access Restriction	Open
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary