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Striatal dopaminergic functioning in patients with sporadic and hereditary spastic paraplegias with parkinsonism.
| Content Provider | Europe PMC |
|---|---|
| Author | Kim, Ji Seon Kim, Jong Min Kim, Yu Kyeong Kim, Sang Eun Yun, Ji Young Jeon, Beom S. |
| Copyright Year | 2013 |
| Abstract | Sporadic spastic paraplegia (SSP) and hereditary spastic paraplegia (HSP) belong to a clinical and genetically heterogeneous group of disorders characterized by progressive spasticity and weakness in the lower extremities. The symptoms are associated with pyramidal tract dysfunction and degeneration of the corticospinal tracts. Parkinsonism is uncommon in SSP/HSP patients. However, both disorders are associated with damage to the nigrostriatal dopaminergic system. In the present study, the clinical features of patients with SSP/HSP were investigated, and nigrostriatal dopaminergic binding potential was assessed using dopamine transporter (DAT) single-photon emission computer tomography (SPECT). Nine patients with spastic paraplegia participated in the present study. The subjects underwent DAT SPECT using the agent [2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato (3-)-N2,N20,S2,S20]oxo-[IR-(exo-exo)])-[99mTc]technetium ([99mTc]TRODAT-1). The [99mTc]TRODAT-1 SPECT images of five patients appeared normal, whereas the images of four patients revealed reduced striatal ligand uptake. Among the four patients with reduced uptake, two had parkinsonism, and one exhibited periodic limb movements and restless leg syndrome. Our DAT SPECT imaging study shows that reduced DAT density may be observed in patients with parkinsonism. The results of the present study offer an explanation for the spectrum of spastic paraplegia symptoms and the progression of the disorder. |
| ISSN | 10118934 |
| Volume Number | 28 |
| PubMed Central reference number | PMC3835511 |
| Issue Number | 11 |
| PubMed reference number | 24265532 |
| Journal | Journal of Korean Medical Science [J. Korean Med. Sci] |
| e-ISSN | 15986357 |
| DOI | 10.3346/jkms.2013.28.11.1661 |
| Language | English |
| Publisher | The Korean Academy of Medical Sciences |
| Publisher Date | 2013-10-31 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2013 The Korean Academy of Medical Sciences. |
| Subject Keyword | Spastic Paraplegia, Hereditary Parkinsonian Disorders Dopamine Transporter Image |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
