Frequency of microembolic signals in patients with acute ischemic stroke in middle cerebral artery territory treated with aspirin or clopidogrel.

Content Provider	Europe PMC
Author	Hashemilar, Mazyar Farhoudi, Mehdi Hosseini, Samane Moshayedi, Hanieh Savadi Oskoui, Dariush Oghli, Behzad Eskandar Rikhtegar, Reza
Copyright Year	2011
Abstract	BackgroundIn patients with acute stroke and middle cerebral artery (MCA) stenosis, microembolic signals (MES) can predict further cerebral ischemia. Therefore, this study was designed to evaluate the prevalence of MES by transcranial Doppler (TCD) in patients with MCA stenosis under treatment of aspirin or clopidogrel.MethodsA randomized clinical trial was performed on 40 patients with acute ischemic stroke in MCA territory. They were randomly allocated in two groups that treated with aspirin (80 mg daily) or clopidogrel (75 mg daily). Clinical and diagnostic work up was included evaluation of cerebrovascular risk factors, echocardiography, carotid color Doppler and brain imaging. TCD was performed between day 3 and 7 after symptoms onset to detect MES. All high intensity transient signals (HITS) were saved and analyzed offline.ResultsCarotid stenosis was found in 13 (65%) patients of aspirin group and 12 (60%) of clopidogrel group. Four (30.8%) of aspirin group and 5 (41.7) of clopidogrel group had stenosis between 10%-50%. One patient in each group had more than 50% stenosis and the remainder had less than 10%. There was no significant difference between two groups. MES was detected in 6 (30%) of patients treated with aspirin and 4 (20%) of those treated with clopidogrel. It showed no statistically significant differences (P-value=0.46).ConclusionOur results indicate a similar effect of aspirin and clopidogrel on frequency of MES in patients with MCA territory ischemic stroke.
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ISSN	2008384X
Journal	Iranian Journal of Neurology [Iran J Neurol]
Volume Number	10
PubMed Central reference number	PMC3829221
Issue Number	1-2
PubMed reference number	24250837
e-ISSN	22520058
Language	English
Publisher	Tehran University of Medical Sciences
Publisher Date	2011-01-01
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. Copyright © 2011 Iranian Neurological Association, and Tehran University of Medical Sciences
Subject Keyword	Microembolic Signals Transcranial Doppler Middle Cerebral Artery Aspirin Clopidogrel
Content Type	Text
Resource Type	Article
Subject	Neurology