Inflammatory myofibroblastic tumor: a rapidly growing soft tissue mass in the posterior mandible.

Content Provider	Europe PMC
Author	Sah, Parul Byatnal, Aditi Amit Rao, Lakshmi Narayanaswamy, Venkadasalapathy Radhakrishnan, Raghu
Abstract	The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Head and neck IMTs are rarely seen and comprise less than 5 % of tumors. Here we report a case of a 30 year old male who presented with a rapidly enlarging and extremely painful growth in the right posterior mandible, post extraction. Histopathological examination revealed a highly cellular connective tissue stroma comprised of spindle shaped cells arranged in fascicles, admixed with inflammatory cells, predominantly plasma cells. Apart from routine hematological investigations, serum protein electrophoresis was also performed. The final diagnosis was confirmed by a panel of immunomarkers consisting of MPO, CD34, CD20, CD3, CD23, CD138, SMA and ALK. To the best of our knowledge, this is the third case of oral IMT arising from an extraction socket.
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ISSN	1936055X
Volume Number	7
DOI	10.1007/s12105-013-0474-8
PubMed Central reference number	PMC3824806
Issue Number	4
PubMed reference number	23843049
Journal	Head and Neck Pathology [Head Neck Pathol]
e-ISSN	19360568
Language	English
Publisher	Springer US
Publisher Date	2013-07-11
Publisher Place	Boston
Access Restriction	Open
Rights License	© Springer Science+Business Media New York 2013
Subject Keyword	Inflammatory myofibroblastic tumour Inflammatory pseudotumor Gingiva Plasma cells Myofibroblasts Immunohistochemistry
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Pathology and Forensic Medicine Oncology