Amiodarone-induced destructive thyroiditis associated with coronary artery vasospasm and recurrent ventricular fibrillation.

Content Provider	Europe PMC
Author	Brooks, Matthew J. Pattison, David A. Teo, Eliza P. Price, Sarah Gurvitch, Ronen
Copyright Year	2012
Abstract	A 55-year-old male on long-term amiodarone therapy presented with ischaemic chest pain and recurrent unwitnessed syncope. Interrogation of his internal cardiac defibrillator, which had been inserted 4 years earlier, revealed two episodes of ventricular fibrillation, the timing of which corresponded to his syncopal events. Severe spontaneous coronary artery vasospasm was observed on coronary angiogram. Thyroid function testing revealed severe hyperthyroidism with a diagnosis of type 2 amiodarone-induced thyrotoxicosis (AIT) subsequently made. Treatment with prednisolone therapy was commenced and thyroid function rapidly normalized. Prednisolone was weaned without recurrence of hyperthyroidism and on last review, 6 months after initial presentation, he remains free from further chest pain and arrhythmias. Our patient's presentation is a very rare case of AIT-associated coronary artery spasm and documented ischaemic ventricular fibrillation with fortunate survival.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3821493&blobtype=pdf
Page Count	3
ISSN	22350640
Journal	European Thyroid Journal [Eur Thyroid J]
Volume Number	2
DOI	10.1159/000345528
PubMed Central reference number	PMC3821493
Issue Number	1
PubMed reference number	24783040
e-ISSN	22350802
Language	English
Publisher	S. Karger AG
Publisher Date	2012-11-30
Publisher Place	Allschwilerstrasse 10, CH-4055 Basel, Switzerland
Access Restriction	Open
Rights License	Copyright © 2012 European Thyroid Association Published by S. Karger AG, Basel
Subject Keyword	Coronary artery spasm Ventricular fibrillation Amiodarone-induced thyrotoxicosis
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism