NDLI: Concentrations of connective tissue growth factor in patients with nonalcoholic fatty liver disease: association with liver fibrosis.

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Concentrations of connective tissue growth factor in patients with nonalcoholic fatty liver disease: association with liver fibrosis.

Content Provider	Europe PMC
Author	Colak, Yasar Senates, Ebubekir Coskunpinar, Ender Oltulu, Yasemin Musteri Zemheri, Ebru Ozturk, Oguzhan Doganay, Levent Mesci, Banu Yilmaz, Yusuf Enc, Feruze Yilmaz Kiziltas, Safak Ulasoglu, Celal Tuncer, Ilyas
Copyright Year	2012
Abstract	Aim: In this study, we aimed to investigate the relationship between the histological fibrosis stage of nonalcoholic fatty liver disease (NAFLD) and serum connective tissue growth factor (CTGF) to determine the usefulness of this relationship in clinical practice.Methods: Serum samples were collected from 51 patients with biopsy-proven NAFLD and 28 healthy controls, and serum levels of CTGF were assayed by ELISA.Results: Levels of CTGF were significantly higher in patients with NAFLD compared with controls (P = 0.001). The serum CTGF levels were significantly increased, that correlated with histological fibrosis stage, in patients with NAFLD [in patients with no fibrosis (stage 0) 308.2 ± 142.9, with mild fibrosis (stage 1–2) 519.9±375.2 and with advanced fibrosis (stage 3–4) 1353.2 ± 610 ng/l, P < 0.001]. Also serum level of CTGF was found as an independent predictor of histological fibrosis stage in patients with NAFLD (β = 0.662, t = 5.6, P < 0.001). The area under the ROC curve was estimated 0.931 to separate patients with severe fibrosis from patients with other fibrotic stages.Conclusion: Serum levels of CTGF may be a clinical utility for distinguishing NAFLD patients with and without advanced fibrosis.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3810787&blobtype=pdf
ISSN	02780240
Journal	Disease markers [Dis Markers]
Volume Number	33
PubMed Central reference number	PMC3810787
Issue Number	2
PubMed reference number	22846210
e-ISSN	18758630
DOI	10.3233/dma-2012-0907
Language	English
Publisher	IOS Press
Publisher Date	2012-01-01
Access Restriction	Open
Rights License	Copyright © 2012 Hindawi Publishing Corporation.
Subject Keyword	Nonalcoholic fatty liver disease (NAFLD) nonalcoholic steatohepatitis (NASH) connective tissue growth factor (CTGF) fibrosis
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Genetics Clinical Biochemistry Molecular Biology

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