Impact of Korean pine nut oil on weight gain and immune responses in high-fat diet-induced obese mice.

Content Provider	Europe PMC
Author	Park, Soyoung Lim, Yeseo Shin, Sunhye Han, Sung Nim
Copyright Year	2013
Abstract	Korean pine nut oil (PNO) has been reported to have favorable effects on lipid metabolism and appetite control. We investigated whether PNO consumption could influence weight gain, and whether the PNO-induced effect would result in an improvement of immune function in high-fat diet (HFD)-induced obese mice. C57BL/6 mice were fed control diets with 10% energy fat from either PNO or soybean oil (SBO), or HFDs with 45% energy fat from 10% PNO or SBO and 35% lard, 20% PNO or SBO and 25% lard, or 30% PNO or SBO and 15% lard for 12 weeks. The proliferative responses of splenocytes upon stimulation with concanavalin A (Con A) or lipopolysaccharide (LPS), Con A-stimulated production of interleukin (IL)-2 and interferon (IFN)-γ, and LPS-stimulated production of IL-6, IL-1β, and prostaglandin E2 (PGE2) by splenocytes were determined. Consumption of HFDs containing PNO resulted in significantly less weight gain (17% less, P < 0.001), and lower weight gain was mainly due to less white adipose tissue (18% less, P = 0.001). The reduction in weight gain did not result in the overall enhancement in splenocyte proliferation. Overall, PNO consumption resulted in a higher production of IL-1β (P = 0.04). Replacement of SBO with PNO had no effect on the production of IL-2, IFN-γ, IL-6, or PGE2 in mice fed with either the control diets or HFDs. In conclusion, consumption of PNO reduced weight gain in mice fed with HFD, but this effect did not result in the overall improvement in immune responses.
ISSN	19761457
Journal	Nutrition Research and Practice
Volume Number	7
PubMed Central reference number	PMC3796659
Issue Number	5
PubMed reference number	24133613
e-ISSN	20056168
DOI	10.4162/nrp.2013.7.5.352
Language	English
Publisher	The Korean Nutrition Society and the Korean Society of Community Nutrition
Publisher Date	2013-10-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ©2013 The Korean Nutrition Society and the Korean Society of Community Nutrition
Subject Keyword	Pine nut oil obesity high-fat diet immune response inflammatory cytokine
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Food Science