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Effects of zinc supplementation in patients with major depression: a randomized clinical trial.
| Content Provider | Europe PMC |
|---|---|
| Author | Ranjbar, Elham Kasaei, Masoumeh Sabet Mohammad-Shirazi, Minoo Nasrollahzadeh, Javad Rashidkhani, Bahram Shams, Jamal Mostafavi, Seyed-Ali Mohammadi, Mohammad Reza |
| Copyright Year | 2013 |
| Abstract | ObjectiveMajor depression is a mood disorder that causes changes in physical activity, appetite, sleep and weight. Regarding the role of zinc in the pathology of depression, the present study was aimed to investigate the effects of zinc supplementation in the treatment of this disease.MethodsThis study was a double-blind randomized clinical trial. Forty four patients with major depression were randomly assigned to groups receiving zinc supplementation and placebo. Patients in Zinc group received daily supplementation with 25 mg zinc adjunct to antidepressant; Selective Serotonin Reuptake Inhibitors (SSRIs), while the patients in placebo group received placebo with antidepressants (SSRIs) for twelve weeks. Severity of depression was measured using the Beck Depression Inventory at baseline and was repeated at the sixth and twelfth weeks. ANOVA with repeated measure was used to compare and track the changes during the study.ResultsThe mean score of Beck test decreased significantly in the zinc supplement group at the end of week 6 (P < 0.01) and 12 (P < 0.001) compared to the baseline. The mean score of Beck Depression Inventory reduced significantly compared to the placebo group at the end of 12th week (P < 0.05)ConclusionThe results of the present study indicate that zinc supplementation together with SSRIs antidepressant drug improves major depressive disorders more effectively in patients with placebo plus antidepressants (SSRIs). |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3796297&blobtype=pdf |
| ISSN | 17354587 |
| Journal | Iranian Journal of Psychiatry [Iran J Psychiatry] |
| Volume Number | 8 |
| PubMed Central reference number | PMC3796297 |
| Issue Number | 2 |
| PubMed reference number | 24130605 |
| e-ISSN | 20082215 |
| Language | English |
| Publisher | Tehran University of Medical Sciences |
| Publisher Date | 2013-06-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. © 2013 Psychiatry and Psychology Research Center, Tehran University of Medical Sciences |
| Subject Keyword | Major depressive disorder Zinc supplement placebo and Selective Serotonin Reuptake Inhibitors (SSRIs) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
