NDLI: Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer.

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Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer.

Content Provider	Europe PMC
Author	Lee, Kyung Dong Jeong, Young-Il Kim, Da Hye Lim, Gyun-Taek Choi, Ki-Choon
Copyright Year	2013
Abstract	BackgroundAlthough cisplatin is extensively used in the clinical field, its intrinsic toxicity limits its clinical use. We investigated nanoparticle formations of poly(acrylic acid-co-methyl methacrylate) (PAA-MMA) incorporating cisplatin and their antitumor activity in vitro and in vivo.MethodsCisplatin-incorporated nanoparticles were prepared through the ion-complex formation between acrylic acid and cisplatin. The anticancer activity of cisplatin-incorporated nanoparticles was assessed with CT26 colorectal carcinoma cells.ResultsCisplatin-incorporated nanoparticles have small particle sizes of less than 200 nm with spherical shapes. Drug content was increased according to the increase of the feeding amount of cisplatin and acrylic acid content in the copolymer. The higher acrylic acid content in the copolymer induced increase of particle size and decrease of zeta potential. Cisplatin-incorporated nanoparticles showed a similar growth-inhibitory effect against CT26 tumor cells in vitro. However, cisplatin-incorporated nanoparticles showed improved antitumor activity against an animal tumor xenograft model.ConclusionWe suggest that PAA-MMA nanoparticles incorporating cisplatin are promising carriers for an antitumor drug-delivery system.
ISSN	11769114
Journal	International Journal of Nanomedicine
Volume Number	8
PubMed Central reference number	PMC3743654
PubMed reference number	23966778
e-ISSN	11782013
DOI	10.2147/ijn.s48367
Language	English
Publisher	Dove Medical Press
Publisher Date	2013-08-08
Access Restriction	Open
Rights License	The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed. © 2013 Lee et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License.
Subject Keyword	cisplatin nanoparticle poly(acrylic acid-co-methyl methacrylate) ion complexes
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Organic Chemistry Drug Discovery Medicine Biomaterials Biophysics Bioengineering Pharmaceutical Science

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