Intentional weight loss and dose reductions of antihypertensive medications: a retrospective cohort study.

Content Provider	Europe PMC
Author	Shantha, Ghanshyam Palamaner Subash Kumar, Anita Ashok Kahan, Scott Cheah, Sang Yun Cheskin, Lawrence J.
Copyright Year	2013
Abstract	Background Though it is well known that weight loss tends to decrease blood pressure, the quantitative association between the magnitude of weight loss and the effect on the need for antihypertensive medications is not well studied. We analyzed this association among overweight and obese attendees at two outpatient weight management centers. Methods Case records of patients with a body mass index >25 at baseline were analyzed. The weight loss intervention consisted of a calorie-restricted diet (~1,000 kcal/day deficit), a behavior modification plan, and a plan for increasing physical activity. Results The study cohort consisted of 100 participants, and the mean follow-up period was 15 ± 3.5 months. Significant weight loss (12.2 ± 3.4 kg) and systolic/diastolic blood pressure reductions (9.1/6.3 mm Hg) were observed by study exit. For 5, 10, and 15% weight loss, respectively, 3, 39, and 39% of the patients achieved at least 1 discontinuation of any antihypertensive medication, and 8, 42, and 21 dose reductions were achieved. Dose reductions or discontinuations occurred in all classes of antihypertensive medications with similar magnitudes of weight loss. Conclusions Intentional weight loss can potentially result in dose reductions/discontinuations of antihypertensive medications. Our results should be validated with data from larger randomized controlled studies and may help to inform the conduct of a systematic review of prior randomized controlled trials that contain data on medication changes accompanying weight loss.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3743454&blobtype=pdf
Page Count	9
ISSN	16643828
Volume Number	3
DOI	10.1159/000347048
PubMed Central reference number	PMC3743454
Issue Number	1
PubMed reference number	23946722
Journal	Cardiorenal Medicine [Cardiorenal Med]
e-ISSN	16645502
Language	English
Publisher	Karger Publishers
Publisher Date	2013-02-15
Publisher Place	Switzerland
Access Restriction	Open
Rights License	Copyright © 2013 by S. Karger AG, Basel
Subject Keyword	Weight loss Obesity Hypertension Blood pressure Antihypertensive agents
Content Type	Text
Resource Type	Article
Subject	Urology Cardiology and Cardiovascular Medicine