Physicochemical properties and applications of poly(lactic-co-glycolic acid) for use in bone regeneration.

Content Provider	Europe PMC
Author	Félix Lanao, Rosa P. Jonker, Anika M. Wolke, Joop G.C. Jansen, John A. van Hest, Jan C.M. Leeuwenburgh, Sander C.G.
Copyright Year	2013
Abstract	Poly(lactic-co-glycolic acid) (PLGA) is the most often used synthetic polymer within the field of bone regeneration owing to its biocompatibility and biodegradability. As a consequence, a large number of medical devices comprising PLGA have been approved for clinical use in humans by the American Food and Drug Administration. As compared with the homopolymers of lactic acid poly(lactic acid) and poly(glycolic acid), the co-polymer PLGA is much more versatile with regard to the control over degradation rate. As a material for bone regeneration, the use of PLGA has been extensively studied for application and is included as either scaffolds, coatings, fibers, or micro- and nanospheres to meet various clinical requirements.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3690090&blobtype=pdf
Page Count	11
ISSN	19373368
Volume Number	19
DOI	10.1089/ten.teb.2012.0443
PubMed Central reference number	PMC3690090
Issue Number	4
PubMed reference number	23350707
Journal	Tissue Engineering. Part B, Reviews [Tissue Eng Part B Rev]
e-ISSN	19373376
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2013-03-01
Publisher Place	USA
Access Restriction	Open
Rights License	Copyright 2013, Mary Ann Liebert, Inc.
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biochemistry Bioengineering Biomedical Engineering