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Why do we need multifunctional neuroprotective and neurorestorative drugs for Parkinson's and Alzheimer's disorders?
| Content Provider | Europe PMC |
|---|---|
| Author | Youdim, Moussa B. H. |
| Copyright Year | 2010 |
| Abstract | Parkinson’s disease (PD) and Alzheimer’s disease (AD) are severeneurodegenerative disorders, with no drugs that are currently approved toprevent the neuronal cell loss characteristic in brains of patients sufferingfrom PD and AD, and all drug treatments are symptomatic and monomodal in theiraction. Due to the complex pathophysiology, including a cascade of neurotoxicmolecular events that result in neuronal death and predisposition to depressionand eventual dementia, and etiology of these disorders, an innovative approachtowards neuroprotection or neurorestoration (neurorescue) is the development anduse of multifunctional pharmaceuticals which can act at different brain regionsand neurons. Such drugs target an array of pathological pathways, each of whichis believed to contribute to the cascades that ultimately lead to neuronal celldeath. In this short review, we discuss examples of novel multifunctionalligands that may have potential as neuroprotective-neurorestorative therapeuticsin PD and AD, some of which are under development. The compounds discussedoriginate from synthetic chemistry as well as from natural sources. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3678780&blobtype=pdf |
| Journal | Rambam Maimonides Medical Journal [Rambam Maimonides Med J] |
| Volume Number | 1 |
| PubMed Central reference number | PMC3678780 |
| Issue Number | 2 |
| PubMed reference number | 23908783 |
| e-ISSN | 20769172 |
| DOI | 10.5041/rmmj.10011 |
| Language | English |
| Publisher | Rambam Health Care Campus |
| Publisher Date | 2010-10-31 |
| Access Restriction | Open |
| Rights License | This is an open-access article. All its content, except where otherwisenoted, is distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/licenses/by/3.0), which permitsunrestricted use, distribution, and reproduction in any medium, provided theoriginal work is properly cited. Copyright: © 2010 Moussa B. H.Youdim. |
| Subject Keyword | Rasagiline multimodal drugs antiapoptotic neuroprotection neurorestoration Parkinson’s disease Alzheimer’s disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
