NDLI: Posttranscriptional control of human gamma interferon gene expression in transfected mouse fibroblasts.

Content Provider	Europe PMC
Author	Young, H A Varesio, L Hwu, P
Abstract	Human gamma interferon genomic DNA was introduced into NIH 3T3 fibroblasts by calcium phosphate precipitation and was not expressed in these cells at the cytoplasmic mRNA or protein level. Treatment of the transfected cells with cycloheximide (1 microgram/ml) induced the accumulation of cytoplasmic gamma interferon mRNA and biologically active human gamma interferon. Analysis of the nuclear enriched RNA from untreated cells indicated that human gamma interferon mRNA was present, suggesting that cycloheximide may act by inhibiting a specific nuclease or may enhance the processing or transport of the RNA from the nucleus to the cytoplasm. Images
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC367767&blobtype=pdf
ISSN	02707306
Volume Number	6
PubMed Central reference number	PMC367767
Issue Number	6
PubMed reference number	3097511
Journal	Mol Cell Biol
e-ISSN	10985549
DOI	10.1128/mcb.6.6.2253-2256.1986
Language	English
Publisher Date	1986-06-01
Access Restriction	Open
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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