Clinical factors associated with carotid plaque and intima-medial thickness in HIV-infected patients.

Content Provider	Europe PMC
Author	Jeong, Su Jin Kim, Hye Won Ku, Nam Su Han, Sang Hoon Kim, Chang Oh Choi, Jun Yong Song, Young Goo Kim, June Myung
Copyright Year	2013
Abstract	PurposeHIV-infected patients are at increased risk for cardiovascular disease, which may be mediated in part by inflammation. This study aimed to evaluate the risk factors of carotid plaque, and clinical factors associated with carotid atherosclerosis measured by carotid intima-medial thickness (cIMT) in HIV patients.Materials and MethodsClinical and cardiometabolic factors as well as cIMT were prospectively measured in 145 HIV-infected participants who had received combined antiretroviral therapy for ≥6 months. The mean value of the bilateral average cIMT level was used as Mean-IMT in the analysis, and the greatest value among the measured cIMT levels was used as Max-IMT.ResultsAmong 145 patients, 34 (23.4%) had carotid plaque. Multivariate logistic regression analysis revealed three independent risk factors of carotid plaque: old age [odds ratio (OR) 6.16, 95% confidence interval (CI) 1.09-34.88; p=0.040], hypertension (OR 12.62, 95% CI 1.72-92.49; p=0.013) and higher low-density lipoprotein cholesterol (LDL-C) (OR 1.08, 95% CI 1.01-1.16; p=0.039). Levels of estimated glomerular filtration rate were inversely associated with Mean-IMT (r=-0.379, p<0.001) and Max-IMT (r=-0.389, p<0.001). Stepwise multivariate regression analyses revealed that age, total cholesterol and fasting glucose were positively correlated with cIMT, independent of other risk factors.ConclusionThe presence of hypertension, old age and a higher level of LDL-C were independent risk factors of carotid plaque among HIV-infected subjects.
ISSN	05135796
Volume Number	54
PubMed Central reference number	PMC3663240
Issue Number	4
PubMed reference number	23709436
Journal	Yonsei Medical Journal [Yonsei Med. J]
e-ISSN	19762437
DOI	10.3349/ymj.2013.54.4.990
Language	English
Publisher	Yonsei University College of Medicine
Publisher Date	2013-07-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2013
Subject Keyword	Carotid plaque carotid artery intima-media thickness atherosclerosis combined antiretroviral therapy HIV infection
Content Type	Text
Resource Type	Article
Subject	Medicine