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Self-eating: friend or foe? The emerging role of autophagy in idiopathic pulmonary fibrosis.
| Content Provider | Europe PMC |
|---|---|
| Author | Margaritopoulos, George A. Tsitoura, Eliza Tzanakis, Nikos Spandidos, Demetrios A. Siafakas, Nikos M. Sourvinos, George Antoniou, Katerina M. |
| Copyright Year | 2013 |
| Abstract | Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last few years. Mortality in 3–5 years is still 50%. Autophagy, a highly conserved homeostatic mechanism necessary for cell survival, has been recently implicated in the pathogenesis of pulmonary disorders. In this paper we aim to highlight some key issues regarding the process of autophagy and its possible association with the pathogenesis of idiopathic pulmonary fibrosis. |
| ISSN | 23146133 |
| Journal | Biomed Research International |
| Volume Number | 2013 |
| PubMed Central reference number | PMC3652133 |
| PubMed reference number | 23691501 |
| e-ISSN | 23146141 |
| DOI | 10.1155/2013/420497 |
| Language | English |
| Publisher | Hindawi |
| Publisher Date | 2013-04-10 |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2013 George A. Margaritopoulos et al. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology |
