Loading...
Please wait, while we are loading the content...
Post-operative capsular opacification: a review.
| Content Provider | Europe PMC |
|---|---|
| Author | Raj, Shetal M. Vasavada, Abhay R. Johar, S. R. Kaid Vasavada, Vaishali A. Vasavada, Viraj A. |
| Copyright Year | 2007 |
| Abstract | Post-operative capsular opacification is a multifactorial physiological consequence of cataract surgery. Opacification involving the central posterior capsule has a significant impact on high and low contrast acuity and low contrast sensitivity. The assessment of Posterior Capsule Opacification (PCO) on cadaver eyes, experimental studies, culture models and in clinical studies has provided an understanding of its pathogenesis. The proliferation, migration and abnormal differentiation of residual lens epithelial cells and fibers in the capsular bag have been implicated in the pathogenesis of PCO. The incidence and severity of PCO correlates to the meticulous use of surgical techniques, IOL optic edge designs and IOL materials. This article summarizes the clinical studies with recommendations for retarding the development of central PCO. It discusses experiments with pharmacological agents broadly categorized as anti-inflammatory, immuno-modulating, antiproliferative, antiadhering, antitransdifferentiating agents for the prevention of PCO. These studies will remain critical for future endeavors undertaken for eradication of PCO. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3614664&blobtype=pdf |
| ISSN | 15509702 |
| Journal | International Journal of Biomedical Science : IJBS [Int J Biomed Sci] |
| Volume Number | 3 |
| PubMed Central reference number | PMC3614664 |
| Issue Number | 4 |
| PubMed reference number | 23675049 |
| e-ISSN | 15552810 |
| Language | English |
| Publisher | Master Publishing Group |
| Publisher Date | 2007-12-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. © Shetal M. Raj et al. Licensee Master Publishing Group |
| Subject Keyword | posterior capsule opacification capsular opacification cataract phacoemulsification crystalline lens |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
