NDLI: Neuroprotective effect of curcumin on spinal cord in rabbit model with ischemia/reperfusion.

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Neuroprotective effect of curcumin on spinal cord in rabbit model with ischemia/reperfusion.

Content Provider	Europe PMC
Author	Liu, Zhi-Qiang Xing, Shan-Shan Zhang, Wei
Copyright Year	2013
Abstract	Background Ischemic/reperfusion (I/R) injury of the spinal cord is a serious complication that can result from thoracoabdominal aortic surgery. Objective To investigate the neuroprotective effect of curcumin against I/R injury in a rabbit model. Methods A total of 36 rabbits were randomly divided into three groups: sham, I/R, and curcumin-treated group. Rabbits were subject to 30-min aortic occlusion to induce transient spinal cord ischemia. Neurological function was observed after reperfusion and spinal cord segment (L3–L5) was collected for histopathological evaluation. Malondialdehyde (MDA) and total superoxide dismutase (SOD) activity were also assayed. Results Rabbits in I/R group were induced to paraplegia. While after 48-hour treatment, compared with I/R group, curcumin significantly improved neurological function, reduced cell apoptosis and MDA levels as well as increased SOD activity (P < 0.05). Conclusions The results suggest that curcumin, at least in an animal model, can attenuate transient spinal cord ischemic injury potentially via reducing oxidative damage, which may provide a novel approach in the treatment of spinal cord ischemic injury.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3595963&blobtype=pdf
ISSN	10790268
Volume Number	36
PubMed Central reference number	PMC3595963
Issue Number	2
PubMed reference number	23809530
Journal	The Journal of Spinal Cord Medicine [J Spinal Cord Med]
e-ISSN	20457723
DOI	10.1179/2045772312y.0000000028
Language	English
Publisher	Maney Publishing
Publisher Date	2013-03-01
Access Restriction	Open
Rights License	© The Academy of Spinal Cord Injury Professionals, Inc. 2013
Subject Keyword	Curcumin Spinal cord Ischemia/reperfusion injury Rabbits Paraplegia Aneurysm Abdominal Aortic Neuroprotection
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical)

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