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High density lipoproteins and atherosclerosis: emerging aspects.

Content Provider	Europe PMC
Author	Sala, Federica Catapano, Alberico Luigi Norata, Giuseppe Danilo
Copyright Year	2012
Abstract	High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.
ISSN	16715411
Journal	Journal of Geriatric Cardiology : JGC
Volume Number	9
PubMed Central reference number	PMC3545258
Issue Number	4
PubMed reference number	23341845
DOI	10.3724/SP.J.1263.2011.12282
Language	English
Publisher	Science Press
Publisher Date	2012-12-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. Institute of Geriatric Cardiology
Subject Keyword	High density lipoproteins Apolipoprotein Sphingosine-1-phosphate Immune response
Content Type	Text
Resource Type	Article
Subject	Geriatrics and Gerontology Cardiology and Cardiovascular Medicine

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