Effect of hormone replacement therapy (HRT) on periodontal status of postmenopausal women.

Content Provider	Europe PMC
Author	Pizzo, Giuseppe Guiglia, Rosario Licata, Maria E. Pizzo, Ignazio Davis, Joan M. Giuliana, Giovanna
Copyright Year	2011
Abstract	SummaryBackgroundThe risks/benefits balance of hormone replacement therapy (HRT) is controversial. The aim of this study was to assess the periodontal status of a postmenopausal women group receiving HRT and to determine the effects of HRT on clinical measures of periodontal disease.Material/MethodsNinety-one postmenopausal women, 52 taking HRT (HRT+) and 39 not taking HRT (HRT−), completed the study. Clinical parameters measured included visible supragingival plaque, probing pocket depth (PD) and clinical attachment level (CAL). Gingival status was recorded as gingival bleeding on probing (BOP). Previous oral contraceptive use and current and past smoking status were also assessed.ResultsData indicated that PD and CAL were not significantly different between HRT+ patients and HRT− patients (P=0.8067 and P=0.1627, respectively). The HRT+ group exhibited significantly lower visible plaque levels compared to the control group (P<0.0001). The percentage of gingival sites with positive BOP was significantly lower in the HRT+ group compared to the HRT− group (34.85% vs. 65.15%; P=0.0007). Plaque accumulation was also tested in ANCOVA as a possible explanatory variable for the differences observed in gingival bleeding. The ANCOVA showed no significant differences in gingival bleeding between HRT+ and HRT− women (P=0.4677). No significant differences in past smoking status and oral contraceptive use were detected between HRT+ and HRT− women (P=0.9999 and P=0.0845, respectively).ConclusionsThese findings indicated that long-term HRT was not associated with relevant effects on periodontal status and clinical measures of periodontal disease, thus suggesting that HRT may not confer protection against periodontitis in postmenopausal women.
ISSN	12341010
Journal	Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Volume Number	17
PubMed Central reference number	PMC3539527
Issue Number	4
PubMed reference number	21455116
e-ISSN	16433750
DOI	10.12659/msm.881700
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2011-04-01
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. © Med Sci Monit, 2011
Subject Keyword	hormone replacement therapy postmenopause periodontitis gingivitis female
Content Type	Text
Resource Type	Article
Subject	Medicine