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Association between the CTLA-4 +49A/G polymorphism and Graves' disease: A meta-analysis.
| Content Provider | Europe PMC |
|---|---|
| Author | SI, XIAOYU ZHANG, XIUFENG TANG, WENRU LUO, YING |
| Copyright Year | 2012 |
| Abstract | The +49A/G polymorphism of the cytotoxic T-lymphocyte-associated antigen-4 gene (CTLA-4) has been associated with Graves’ disease (GD). However, results have been inconsistent. The aim of this study was to quantitatively summarize the evidence for CTLA-4 +49A/G polymorphism and GD. Electronic search of PubMed was conducted to select studies. Case-control studies containing available genotype frequencies of CTLA-4 +49 were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Forty-two case-control studies including 8,288 cases and 9,372 controls were identified. Three studies were eliminated from the total 42 studies due to a p-value <0.05 (p-value for Hardy-Weinberg equilibrium in control group) in these studies which induced significant publication bias. The overall results suggested that the variant genotypes were highly associated (p<0.01) with GD risk in all genetic models (additive model: OR, 1.443; 95% CI, 1.319–1.578; p<0.001; recessive model: OR, 1.589; 95% CI, 1.396–1.808; p<0.001; dominant model: OR, 1.621; 95% CI, 1.430–1.837; p<0.001). Similarly, in the subgroup analyses for ethnicity (Caucasian, Asian), the results were positive. This meta-analysis suggests that the CTLA-4 +49A/G polymorphism is highly associated (p<0.01) with increased risk of GD, especially in Caucasians and Asians. To validate this association, further studies with larger participants worldwide are needed to examine associations between this polymorphism and GD. |
| ISSN | 17920981 |
| Journal | Experimental and Therapeutic Medicine |
| Volume Number | 4 |
| PubMed Central reference number | PMC3503798 |
| Issue Number | 3 |
| PubMed reference number | 23181132 |
| e-ISSN | 17921015 |
| DOI | 10.3892/etm.2012.618 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2012-06-20 |
| Access Restriction | Open |
| Rights License | This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2012, Spandidos Publications |
| Subject Keyword | cytotoxic T-lymphocyte-associated antigen-4 gene autoimmune thyroid diseases Graves’ disease meta-analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Cancer Research |
