Loading...
Please wait, while we are loading the content...
Similar Documents
Osteogenic differentiation of human placenta-derived mesenchymal stem cells (PMSCs) on electrospun nanofiber meshes.
| Content Provider | Europe PMC |
|---|---|
| Author | Zhang, Dongmei Tong, Aiping Zhou, Liangxue Fang, Fang Guo, Gang |
| Abstract | Numerous challenges remain in the successful clinical translation of cell-based therapeutic studies for skeletal tissue repair, including appropriate cell sources and viable cell delivery systems. Poly(ethylene glycol)-poly(ε-caprolactone) (PEG-PCL) amphiphilic block copolymers have been extensively explored in microspheres preparation. Due to the introduction of hydrophilic PEG segments into PCL backbones, these copolymers have shown much more potentials in carrying protein, lipophilic drugs or genes than commonly used poly (ε-caprolactone) (PCL) and poly (lactic acid). The aim of this study is to investigate the attachment and osteogenic differentiation of human placenta derived mesenchymal stem cells (PMSCs) on PEG-PCL triblock copolymers nanofiber scaffolds. Here we demonstrated that PMSCs proliferate robustly and can be effectively differentiated into osteogenic-like cells on nanofiber scaffolds. This study provides evidence for the use of nanofiber scaffolds as an ideal supporting material for in vitro PMSCs culture and an in vivo cell delivery vehicle for bone repair. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3488365&blobtype=pdf |
| ISSN | 09209069 |
| Volume Number | 64 |
| DOI | 10.1007/s10616-012-9450-5 |
| PubMed Central reference number | PMC3488365 |
| Issue Number | 6 |
| PubMed reference number | 22526490 |
| Journal | Cytotechnology |
| e-ISSN | 15730778 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2012-04-15 |
| Publisher Place | Dordrecht |
| Access Restriction | Open |
| Rights License | © Springer Science+Business Media B.V. 2012 |
| Subject Keyword | Placenta derived human mesenchymal stem cells (PMSCs) Osteogenic differentiation Electrospun nanofiber scaffolds |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Clinical Biochemistry Bioengineering Biomedical Engineering Biotechnology |
