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Optical stirring in a droplet cell bioreactor.
| Content Provider | Europe PMC |
|---|---|
| Author | Muradoglu, Murat Le, Thuong Lau, Chun Yat Liew, Oi Wah Ng, Tuck Wah |
| Copyright Year | 2012 |
| Abstract | In the context of a bioreactor, cells are sensitive to cues from other cells and mechanicalstimuli from movement. The ability to provide the latter in a discrete fluidic system presentsa significant challenge. From a prior finding that the location of the focus of a laser belowparticles relative to the beam axis producing a pushing effect in a predominant lateral sense,we advance an approach here that generates a gentle and tunable stirring effect. Computersimulation studies show that we are able to characterize this effect from the parameters thatgovern the optical forces and the movement of the particles. Experimental results withpolystyrene microbeads and red blood cells confirm the notions from the simulations. |
| Journal | Biomedical Optics Express |
| Volume Number | 3 |
| PubMed Central reference number | PMC3469996 |
| Issue Number | 10 |
| PubMed reference number | 23082288 |
| e-ISSN | 21567085 |
| DOI | 10.1364/BOE.3.002465 |
| Language | English |
| Publisher | Optical Society of America |
| Publisher Date | 2012-09-12 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative CommonsAttribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download andredistribution, provided that the original work is properly cited. This license restricts thearticle from being modified or used commercially. ©2012 Optical Society of America |
| Subject Keyword | (170.4520) Optical confinement and manipulation (170.3890) Medical optics instrumentation (140.7010) Laser trapping |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biotechnology Atomic and Molecular Physics, and Optics |
