Alcohol consumption and mortality in the Korean Multi-Center Cancer Cohort Study.

Content Provider	Europe PMC
Author	Jung, En-Joo Shin, Aesun Park, Sue K. Ma, Seung-Hyun Cho, In-Seong Park, Boyoung Lee, Eun-Ha Chang, Soung-Hoon Shin, Hai-Rim Kang, Daehee Yoo, Keun-Young
Copyright Year	2012
Abstract	ObjectivesTo examine the association between alcohol consumption habit, types of beverages, alcohol consumption quantity, and overall and cancer-specific mortality among Korean adults.MethodsThe alcohol consumption information of a total of 16 320 participants who were 20 years or older from the Korean Multi-center Cancer Cohort were analyzed to examine the association between alcohol consumption habit and mortality (median follow-up of 9.3 years). The Cox proportional hazard model was used to estimate the hazard ratio (HR) of alcohol consumption to mortality adjusting for age, sex, geographic areas, education, smoking status, and body mass index.ResultsAlcohol drinkers showed an increased risk for total mortality compared with never drinkers (HR, 1.72; 95% confidence interval [CI], 1.38 to 2.14 for past drinkers; HR, 1.21; 95% CI, 1.06 to 1.39 for current drinkers), while past drinkers only were associated with higher risk for cancer deaths (HR, 1.84; 95% CI, 1.34 to 2.53). The quantity of alcohol consumed per week showed a J-shaped association with risk of mortality. Relative to light drinkers (0.01 to 90 g/wk), never drinkers and heavy drinkers (>504 g/wk) had an increased risk for all-cause and cancer deaths: (HR, 1.18; 95% CI, 0.96 to 1.45) and (HR, 1.39; 95% CI, 1.05 to 1.83) for all-cause mortality; and (HR, 1.55; 95% CI, 1.15 to 2.11) and (HR, 2.07; 95% CI, 1.39 to 3.09) for all cancer mortality, respectively. Heavy drinkers (>504 g/wk) showed an elevated risk for death from stomach and liver cancers.ConclusionsThe present study supports the existence of a J-shaped association between alcohol consumption quantity and the risk of all-cause and cancer deaths. Heavy drinkers had an increased risk of death from cancer overall and liver and stomach cancer.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3469812&blobtype=pdf
ISSN	19758375
Journal	Journal of Preventive Medicine and Public Health [J Prev Med Public Health]
Volume Number	45
DOI	10.3961/jpmph.2012.45.5.301
PubMed Central reference number	PMC3469812
Issue Number	5
PubMed reference number	23091655
e-ISSN	22334521
Language	English
Publisher	The Korean Society for Preventive Medicine
Publisher Date	2012-09-28
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2012 The Korean Society for Preventive Medicine
Subject Keyword	Alcohol drinking Mortality Korean Multi-center Cancer Cohort Korea
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health