NDLI: The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look.

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The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look.

Content Provider	Europe PMC
Author	Clark, Andrew R Dean, Jonathan LE
Copyright Year	2012
Abstract	The p38 mitogen-activated protein kinase (MAPK) signaling pathway has been strongly implicated in many ofthe processes that underlie the pathology of rheumatoid arthritis (RA). For many years it has been considered a promisingtarget for development of new anti-inflammatory drugs with which to treat RA and other chronic immune-mediatedinflammatory diseases. However, several recent clinical trials have concluded in a disappointing manner. Why is this so, ifp38 MAPK clearly contributes to the excessive production of inflammatory mediators, the destruction of bone andcartilage? We argue that, to explain the apparent failure of p38 inhibitors in the rheumatology clinic, we need tounderstand better the complexities of the p38 pathway and its many levels of communication with other cellular signalingpathways. In this review we look at the p38 MAPK pathway from a slightly different perspective, emphasising its role inpost-transcriptional rather than transcriptional control of gene expression, and its contribution to the off-phase rather thanthe on-phase of the inflammatory response.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3460412&blobtype=pdf
Journal	The Open Rheumatology Journal [Open Rheumatol J]
Volume Number	6
DOI	10.2174/1874312901206010209
PubMed Central reference number	PMC3460412
PubMed reference number	23028406
e-ISSN	18743129
Language	English
Publisher	Bentham Open
Publisher Date	2012-09-07
Access Restriction	Open
Rights License	This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. © Clark and Dean; Licensee Bentham Open.
Subject Keyword	p38 MAPK inflammatory mediators gene expression phosphorylation listeria monocytogenes.
Content Type	Text
Resource Type	Article
Subject	Rheumatology

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