NDLI: Oxidative stress and antioxidants in tubercular meningitis.

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Oxidative stress and antioxidants in tubercular meningitis.

Content Provider	Europe PMC
Author	Sudha, K Rao, Ashalatha V Rao, S. N. Rao, Anjali
Abstract	Oxidative stress is implicated in the etiopathogenesis of a variety of human diseases. Therefore, in the present study, erythrocyte lipid peroxidation, percentage hemolysis, antioxidant enzymes viz., glutathione reductase, glutathione peroxidase, superoxide dismutase and plasma antioxidants viz., ceruloplasmin, vitamins A,E and C have been determined in 19 patients with tubercular meningitis (TBM) and 50 normals. Six patients who were treated with antibiotics were considered for the follow up. The statistical analysis was carried out by Mann Whitney U test and Wilcoxon rank sum test. Lipid peroxidation (P<0.02), percentage hemolysis (P<0.001) and plasma ceruloplasmin (P<0.0001) of TBM patients were significantly higher, whereas erythrocyte glutathione reductase (P<0.05) and plasma antioxidant vitamins A, E and C (P<0.01, P<0.05 respectively) were significantly lower than those of the controls. In the follow up patients the glutathione reductase and catalase levels were significantly high (P<0.05) compared to their pre-treated condition. Vitamin C and E levels have attained normal range. This study indicated that the blood antioxidant status of TBM patients which was low compared to controls improved after treatment, suggesting the role of free radicals in TBM.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3453718&blobtype=pdf
ISSN	09701915
Volume Number	17
PubMed Central reference number	PMC3453718
Issue Number	1
PubMed reference number	23105334
Journal	Indian Journal of Clinical Biochemistry [Indian J Clin Biochem]
e-ISSN	09740422
DOI	10.1007/bf02867939
Language	English
Publisher	Springer India
Publisher Date	2002-01-01
Publisher Place	New Delhi
Access Restriction	Open
Rights License	© Association of Clinical Biochemists of India 2002
Subject Keyword	Antioxidant enzymes antioxidant vitamins lipid peroxidation tubercular meningitis
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry

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